Monday, April 29, 2013

How does pregnancy reduce breast cancer risk?

Apr. 28, 2013 ? Being pregnant while young is known to protect a women against breast cancer. But why? Research in BioMed Central's open access journal Breast Cancer Research finds that Wnt/Notch signalling ratio is decreased in the breast tissue of mice which have given birth, compared to virgin mice of the same age.

Early pregnancy is protective against breast cancer in humans and in rodents. In humans having a child before the age of 20 decreases risk of breast cancer by half. Using microarray analysis researchers from Basel discovered that genes involved in the immune system and differentiation were up-regulated after pregnancy while the activity of genes coding for growth factors was reduced.

The activity of one particular gene Wnt4 was also down-regulated after pregnancy. The protein from this gene (Wnt4) is a feminising protein -- absence of this protein propels a fetus towards developing as a boy. Wnt and Notch are opposing components of a system which controls cellular fate within an organism and when the team looked at Notch they found that genes regulated by notch were up-regulated, Notch-stimulating proteins up-regulated and Notch-inhibiting proteins down-regulated.

Wnt/Notch signalling ratio was permanently altered in the basal stem/progenitor cells of mammary tissue of mice by pregnancy. Mohamed Bentires-Alj from the Friedrich Miescher Institute for Biomedical Research, who led this study explained, "The down-regulation of Wnt is the opposite of that seen in many cancers, and this tightened control of Wnt/Notch after pregnancy may be preventing the runaway growth present in cancer."

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The above story is reprinted from materials provided by BioMed Central.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Fabienne Meier-Abt, Emanuela Milani, Tim Roloff, Heike Brinkhaus, Stephan Duss, Dominique S Meyer, Ina Klebba, Piotr J Balwierz, Erik van Nimwegen and Mohamed Bentires-Alj. Parity induces differentiation and reduces Wnt/Notch signaling ratio and proliferation potential of basal stem/progenitor cells isolated from mouse mammary epithelium. Breast Cancer Research, 2013 (in press) [link]

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/M01wkIKwjeM/130428230427.htm

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Holocaust survivors, veterans gather at DC museum

WASHINGTON (AP) ? Elderly survivors of the Holocaust and the veterans who helped liberate them gathered for what could be their last big reunion Monday at the U.S. Holocaust Memorial Museum.

One thousand survivors and World War II vets joined with former President Bill Clinton and Nobel Peace Prize laureate and Holocaust activist Elie Wiesel to mark the museum's 20th anniversary. Organizers chose not to wait for the 25th milestone because many survivors and vets may not be alive in another five or 10 years.

"We felt it was important, while that generation is still with us in fairly substantial numbers, to bring them together," said Museum Director Sara Bloomfield.

Washington has many monuments and memorials that offer something special for visitors from around the world, "but the Holocaust memorial will be our conscience," Clinton said.

Since the museum opened 20 years ago, the world has made huge scientific discoveries, including the sequencing of the human genome, which proved humans are 99.5 percent genetically the same, Clinton said.

"Every non age-related difference ... is contained in one half of 1 percent of our genetic makeup, but every one of us spends too much time on that half a percent," Clinton said. "That makes us vulnerable to the fever, the sickness that the Nazis gave to the Germans. That sickness is very alive across the world today."

The occasion marked a reunion of sorts for Clinton and Wiesel as well: Both were on hand to dedicate the museum at its opening in 1993. On Sunday night, the museum presented its highest honor to World War II veterans who helped end the Holocaust. Susan Eisenhower accepted the award on behalf of her grandfather, U.S. Gen. Dwight D. Eisenhower, and all veterans of the era.

The museum also launched a campaign to raise $540 million by 2018 to keep the memory of the Holocaust alive and to combat anti-Semitism, Holocaust denial and contemporary genocide. It has already secured gifts totaling $258.7 million. The campaign aims to double the size of the museum's endowment by its 25th anniversary. Also, a $15 million gift from Holocaust survivors David and Fela Shapell will help build a new collections and conservation center.

Bloomfield said organizers wanted to show Holocaust survivors, veterans and rescuers that the effort will continue to honor the memory of 6 million murdered Jews, in part by working to prevent genocide in the future.

Vera Greenwood, who was born in Berlin and remembers as a girl seeing Hitler with Nazis marching in the street, said her father knew they had to leave when he was forced out of his job as a lawyer. She remembers Nazi officers coming to their house and taking her father's books.

"Though I was very young, I knew something was very wrong," said Greenwood, now 84. "I still feel we were very lucky to survive."

Her family moved to Palestine with a British visa and ended up fighting for Israel's independence. Greenwood lived in Israel for 30 years before immigrating to the U.S. and completing a doctorate at Arizona State University.

She and her husband, Fred, who survived the Holocaust in Holland as a child by being hidden and passed from house to house, wanted to be part of the last large reunion of survivors.

"In 10 more years, most of us will be gone," Greenwood said.

The museum continues collecting objects, photographs and other evidence of the Holocaust from survivors, veterans and archives located as far away as China and Argentina. Curators expect the collection to double in size over the next decade.

This week, the museum is opening a special, long-term exhibit titled "Some Were Neighbors: Collaboration and Complicity During the Holocaust." It includes interviews with perpetrators that have never been shown before, as well as details of mass killings in the former Soviet Union that were only uncovered in more recent years.

Curator Susan Bachrach said the exhibit and its research challenge the idea that the Holocaust was primarily about Hitler and other Nazi leaders. Surveys at the museum show that's what most visitors believe.

"That's very comforting to people, because it puts distance between the visitors and who was involved," Bachrach said.

So, the museum set out to look at ordinary people who looked on and were complicit in the killing and persecution of millions of Jews through greed, a desire for career advancement, peer pressure or other factors. It examines influences "beyond hatred and anti-Semitism," Bachrach said.

Focusing only on fanatical Nazis would be a serious misunderstanding of the Holocaust, Bloomfield added.

"The Holocaust wouldn't have been possible, first of all, without enormous indifference throughout Germany and German-occupied Europe, but also thousands of people who were, say, just doing their jobs," she said, such as a tax official who collected special taxes levied against Jews.

In an opening film, some survivors recall being turned over to Nazi authorities in front of witnesses who did nothing. "The whole town was assembled ... looking at the Jews leaving," one survivor recalls.

Steven Fenves was a boy at the time. He recalled how in 1944, the government of Hungary, allied with Nazi Germany, forced his family out of its apartment. The family was deported to Auschwitz, where Fenves' mother was gassed.

"One of the nastiest memories I have is going on that journey and people were lined up, up the stairs, up to the door of the apartment, waiting to ransack whatever we left behind, cursing at us, yelling at us, spitting at us as we left," he said in an interview with the museum.

The museum located images of bystanders looking on as Jews were detained, humiliated and taken away.

Non-Jews were also punished for violating German policies against the mixing of ethnic groups. For the first time, the museum is showing striking, rare footage of a ritualistic shaming of a Polish girl and a German boy for having a relationship. They are marched through the streets of a town in Poland, where the film was located in an attic. Dozens of people look on as Nazi officers cut the hair of the two teenagers. They are forced to look at their nearly bald heads in a mirror before their hair is burned.

The federally funded museum's theme for its 20th anniversary is "Never Again: What You Do Matters." The museum devotes part of its work and research to preventing future genocides. A study released by the museum last month found that the longer the current conflict in Syria continues, the greater the danger that mass sectarian violence results in genocide.

Much more is still being learned about the Holocaust, as well, Bloomfield said. The museum is compiling an encyclopedia of all incarceration sites throughout Europe. When the project began, scholars expected to list 10,000 such sites. Now the number stands at 42,000.

Since opening, the museum has had more than 35 million visitors.

___

U.S. Holocaust Memorial Museum: http://www.ushmm.org

___

Follow Brett Zongker on Twitter at https://twitter.com/DCArtBeat

Source: http://news.yahoo.com/holocaust-survivors-veterans-gather-dc-museum-095000298.html

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Kentucky woman ordained as priest by dissident Roman Catholics

John Sommers / Reuters

Ordaining Bishop Bridget Mary Meehan (C) presents Rosemarie Smead (R), a 70-year-old Kentucky woman, to the audience after she was ordained as a Roman Catholic priest during a Celebration of Ordination at St. Andrew's United Church of Christ in Louisville, Kentucky April 27, 2013.

By Sofia Perpetua, NBC News

A dissident Roman Catholic group ordained a 70-year-old woman a priest in Louisville, Kentucky, during a ceremony attended by hundreds on Saturday.

About 150 women from all over the world have been ordained in defiance of the Roman Catholic Church that bans them from becoming priests.

Rosemarie Smead will be starting her own congregation and she told Reuters she is not worried about being excommunicated.

"It is a medieval bullying stick the bishops used to keep control over people and to keep the voices of women silent,? she said. ?I am way beyond letting octogenarian men tell us how to live our lives."

Smead, a former Carmelite nun with a bachelor's in theology and a doctorate in counseling psychology, wept throughout the ceremony.

According to a recent New York Times/CBS News poll, seventy percent of U.S. Catholics believe women should be allowed to be priests.

In a statement last week, Louisville Archbishop Joseph E. Kurtz called the planned ceremony by the Association of Roman Catholic Women Priests a "simulated ordination" in opposition to Catholic teaching.

"The simulation of a sacrament carries very serious penal sanctions in Church law, and Catholics should not support or participate in Saturday's event," Kurtz said.

Reuters contributed to this story

Source: http://feeds.nbcnews.com/c/35002/f/653381/s/2b479a89/l/0Lusnews0Bnbcnews0N0C0Inews0C20A130C0A40C280C179592150Ekentucky0Ewoman0Eordained0Eas0Epriest0Eby0Edissident0Eroman0Ecatholics0Dlite/story01.htm

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SoftBank allows Sprint to conduct talks with Dish

OVERLAND PARK, Kan. (AP) ? Sprint Nextel says SoftBank is allowing it to seek more information from Dish Network related to its rival bid for the third-largest U.S. cellphone company.

Overland Park, Kan.-based Sprint has agreed to sell 70 percent of itself to Japan's Softbank Corp. for $20.1 billion. But it recently got a competing $25.5 billion offer from Dish Network Corp. for the whole company.

Under the agreement with SoftBank, Sprint can enter into a non-disclosure agreement and talks with Dish so it can clarify and obtain additional information from Dish related to its bid for the company.

Sprint isn't allowed to provide non-public information to Dish and can't enter into negotiations with the company.

SoftBank says it remains confident in its offer and expects the deal to close in July.

Source: http://news.yahoo.com/softbank-allows-sprint-conduct-talks-dish-124339338.html

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President Obama Pokes Fun at Jay-Z & Taylor Swift!

Barack Obama is a controversial president, but we hope everyone can agree on one thing: The guy can land a punchline. At Saturday's annual White House Correspondents Dinner, the president gave a scathingly funny speech, lampooning himself, the press, Congress, and a few A-list celebrities. If he wasn't funnier than the evening's host Conan O'Brien, he definitely gave him a run for his money! Check out Obama's 7 best zingers, including shots at Jay-Z and Taylor Swift, below.

Source: http://www.ivillage.com/obama-jokes-about-jay-z-taylor-swift-correspondents-dinner/1-a-534532?dst=iv%3AiVillage%3Aobama-jokes-about-jay-z-taylor-swift-correspondents-dinner-534532

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Friday, April 26, 2013

The Winds of Change | Periodicals Price Survey 2013 - Library Journal

The stock market has hit record highs, and unemployment has reached the lowest level since the recession began. Despite this good news, the library economic environment has not seen commensurate improvement. There continues to be a struggle to find the resources needed to support library collections and services, and conditions remain highly unsettled.

According to the National Association of State Budget Officers, 24 states are working from 2013 budgets with lower general fund expenditures in FY13 than in 2008, the last year before the recession. Nearly half the states have not returned to prerecession levels of revenue and spending. Overall, total general fund expenditures for all states will not exceed the pre?recession high of $687.3 billion spent in FY08. Funding for K-12 education has seen a little relief as a total of $4.9 billion was added to state budgets overall, but higher education is still seeing cuts, as 16 states reduced allocations for higher education by a total of just over $1 billion.

ljx130501webPeriodicalTb1 The Winds of Change | Periodicals Price Survey 2013

(All tables are labeled to correspond to the print layout of this article, and so appear out of order below for this web presentation)

Meanwhile, sequestration is not going to make state and local funding problems any easier. Historically, the federal government provides about one-quarter of all state revenues, and owing to sequestration, the federal government is now poised to make deep spending cuts. If a significant portion of sequestration is left in place, federal funding for schools and other non-entitlement grants to states are on track to reach their lowest levels in four decades, measured as a share of the economy.

The lack of public funding translated to flat funding in libraries. Data from the Association of Research Libraries (ARL) shows that median total expenditures for ARL libraries dropped slightly from 2011 to 2012 ($24,052,161 to $24,000,677). Since the ARL members are a mixture of public and private organizations, increases in expenditures by the private universities helped offset declines in spending from the public universities and the overall result was a slight decrease in expenditures.

There is good economic news out there, but most libraries that rely on public funding have not fully recovered from the recession. Flat budgets and ongoing inflation in costs are forcing libraries to continue to find creative ways to keep current services. In this environment, disproportionate serials prices are thrown into greater relief.

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This year, the serials pricing data indicates that prices are increasing at about the same rate as last year. Increases seemed to have plateaued at about 6% for 2013. Data from the merged ISI indexes shows a 6% increase for 2013, unchanged from 2012. EBSCO?s MasterFILE Premier and Academic Search Premier show similar results: average prices for titles in MSP increased 5% for 2013, while average prices for titles in ASP increased 6% in 2013, the same increase as for 2012. The Consumer Price Index (CPI), on the other hand, advanced 1.7% for 2012, which means serials inflation continues to far exceed general inflationary pressures and library budget adjustments. Serials prices showed restraint in 2010, but since that time they have risen steadily, and budgets have not. The price increases are not driven by science, technology, and medical (STM) prices since education and library science showed the highest increases, 9%, in 2013 ISI data, while the numbers from ASP showed anthropology and health sciences increasing at the 9% levels.

Average prices for STM serials remain the highest, compared with prices for serials in other subject areas. Chemistry has historically seen the highest average serials prices, and that has not changed: recent reports show that the average price for chemistry journals hovers around $4,450 annually. There were only slight shifts in the overall average prices for serials broken down by subject area although food science did climb up the list by several spots from 2012.

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Price, value, & expenditure

It has been the intent of this article to present the most reliable information concerning serials pricing as is reasonably possible to produce, and the current version of the price survey has now been published for over 20 years by LJ. Based on the ANSI/NISO Z39.20-1999 Criteria for Price Indexes for Printed Library Materials, this price survey uses the available retail print price for subscriptions for titles that are listed in indexes widely used in the United States. The actual change in the retail price is measured year to year to gauge the overall increase in serial prices.

Unlike print, published retail rates are not available for all of the titles in the combined indexes. Starting in 2011, Average Price for Online Journals in the ISI Indexes, has documented the average cost per subject area where standard online pricing is available. This fall, the Professional Scholarly Publishing Bulletin published an article by Paula Gantz that suggested serial price has now been replaced by digital licenses as the true reflection of real journal costs. In the article, the author directly questions the validity of this study by suggesting that the ?effective? price increase for an average journal was only 9% higher in 2010 as compared to 1990, not the six-fold increase documented over the years in this price study.

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There are good points raised by Gantz concerning the increased value derived from digital licenses and how the increase in research has resulted in increased content. There do need to be more substantive discussions concerning these issues and the failure of libraries to secure their piece of the research funding pie. However, the contention that the effective price of the average journal has only increased 9% and that the price of journals accessed in the UK has actually gone down 11% since 2004 cannot be accepted without much more data substantiating those claims. After searching the reports cited in the UK study, no reference to the cited data could be found. If this is derived data then the source for the primary data and the methodology used to derive the figure need to be documented.

Those who has been involved with purchasing serials in the last 20 years know that serial prices have increased significantly and represent the largest inflationary factor for library budgets. To suggest that the real increase in serial prices is only 9% flies in the face of reality. The author derived the figure by using data from ARL that reported changes in the number of purchased serials and serial expenditures for the period 1990?2010. While the data does show that the numerical value resulting from dividing expenditures by the number of purchased serials did increase 9% over that period, to conclude that prices only increased 9% is incorrect. Between 1990 and 2010, ARL changed the definition of purchased serials. In 1990, the definition was based on subscribed titles. In 2010, the definition used by ARL had changed considerably: ?Report the total number of unique serial titles, NOT SUBSCRIPTIONS, that you currently acquire and to which you provide access?. Report each title once, regardless of how many subscriptions or means of access you provide for that title? (definitions for 2010 and 2011 are essentially unchanged).

The majority of the increase in the number of serials purchased reported over this period is due to the inclusion of titles purchased through databases and similar aggregations, not through ?big deal? packages. The cost of the access provided to these journals by libraries cannot be compared to the retail price of subscribed content. These are very different things.

ljx130501webPeriodicalTb81 The Winds of Change | Periodicals Price Survey 2013

Price, value, and expenditure are likewise different entities. While related, the means of measurement and assessment of these items must be considered individually. The value of content is an important factor to consider when making purchasing decisions, but the price on the invoice is what impacts the budget, and there needs to be reliable information on changes in price to assist with budget planning. The $50,000 sports car discounted to $25,000 may be the best value, but if the budget only has room for a $10,000 used compact, that is what you buy.

Geography & discipline

There was little change in the relative order for the average price per title sorted by country of origin. While the average price per title decreased slightly from 2012, titles from Russia and Ireland continue to have the highest cost per title for all included in the merged ISI indexes. Hungary, Austria, the Netherlands, Singapore, Germany, Switzerland, Greece (replacing the United States in the Top 10), and England round out the Top 10 countries with the highest cost per title in 2013. It will be interesting to see the impact of open access initiatives upon 2014 pricing, especially in England where government initiatives mandated open access for publicly funded research by April 2013.

Table 9 once again examines the titles in the combined ISI Arts and Humanities, Science Citation, and Social Sciences Citation indexes, which offer published rates for online formats. As in past years, the data reflects online only, print plus free online, and the first tier of any tiered pricing, with the common element being pricing for the online format.

Elsevier, Wiley, Springer, Taylor & Francis, and SAGE still dominate the combined indexes with more than half of the titles; 3% of titles in the combined indexes are open access. The 2013 average cost for this set of titles is $1,184. While that reflects an increase of 3% over last?s year?s average price of $1,147, it is important to keep in mind that the individual titles and associated pricing models reflected by Table 9 change each year and may have been impacted by the number of factors, including the number of open access titles included in the ISI indexes this year.

New business models

While the debate over the Big Deal continues, ?The State of Large-Publisher Bundles in 2012,? authored by Karla Strieb and Julia Blixrud and published by ARL, documents the market penetration and continued dominance of packaged content in ARL libraries. The authors? analysis of survey responses from 81 ARL member libraries conducted during the summer of 2012 revealed that more than 85 percent subscribed to e-journal packages from the American Chemical Society, Wiley, Springer, Elsevier, SAGE, and Nature in 2012. The study also documents the shift in the definition of the e-journal package from all the titles offered by the publisher to consortially or individually defined collections. The survey likewise addresses the shift from bundled print and e-journal subscriptions to electronic-only format, with respondents reporting selected retention of print for all publishers except Taylor & Francis.

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A comparison of the publisher e-journal packages ordered by 619 major clients of EBSCO Information Services in both 2012 and 2013 reflected an average price increase of 5.5%, comparable to this year?s overall 6% print/online price increase. When the price analysis was made comparing similar tiers or other fixed criteria (tier 3 pricing compared to tier 3 pricing, Carnegie level 4 compared to Carnegie level 4, etc.), the price difference for the packages between 2012 and 2013 reflected an average 7.12% ?increase.

Open access

Spring 2012 brought renewed emphasis on open access as diminished academic library budgets and the steady increase in the cost of journal literature converged, resulting in stronger mandates regarding the availability of government-funded research from groups including Britain?s Wellcome Trust, Research Council UK, and the U.S. National Institutes of Health. The Report of the Working Group on Expanding Access to Published Research Findings, popularly known as the Finch Report, explored the difficult issues of funding as well as access models. Operating on a different scale and model from traditional publications offering green, gold, and hybrid open access options, the Public Library of Science (PLoS) was joined in 2012 by the megajournal offering from PeerJ.

With bipartisan support, in February of this year, the Fair Access to Science and Technology Research Act (FASTR) was introduced in both the U.S. House and the Senate. FASTR would require federal agencies with research expenditures of over $100 million per year to make articles resulting from the funding freely available online (and notably available openly for ?computational analysis,? according to the bill) within six months of publication. Meanwhile, the Obama administration?s Office of Science and Technology Policy (OSTP) issued a sweeping memo in February prompting many of the policies argued for by FASTR, though with a longer 12-month embargo. However, open access advocates are still pushing for Congressional passage of the bill to enshrine the mandate as law rather than policy subject to executive branch discretion.

SCOAP3, the Sponsoring Consortium for Open Access Publishing in Particle Physics, working with CERN, the European Organization for Nuclear Research, moved forward in 2012 with the announcement of agreements with seven publishers covering 12 journals in high-energy physics. Earlier this year, in announcing new members representing 31 countries worldwide, SCOAP3 stated that the 85% of the anticipated required funding had been secured to transition the 12 journals to open access by 2014.

Widely embraced by the sciences where funding is more plentiful, the open access mandates have been less enthusiastically received by some in the humanities. A recent survey of authors who publish in Taylor & Francis/Routledge journals reported that 33% think that research outputs will be published as open access with some restrictions on reuse, while 51% of respondents think that research outputs will continue be published in subscription journals.

Philosophical issues aside, with the 2012 open access market estimated at $172 million by Outsell, open access is a business model. Funding will still be required to support the green, hybrid, and gold open access or subscription/membership costs. As has been discussed in previous serials pricing articles, open access options are currently being offereing by all the major publishers, such as Springer?s Biomed Central, Wiley Open Access, and SAGE Open. Traditional intermediaries such as EBSCO and the Copyright Clearance Center have joined new companies such as Open Access Key in providing services to streamline the management of author processing charges and related fees.

2014 forecast

The 2014 journal marketplace will continue to be unsettled as the traditional elements of budget, price, and value collide with the new forces of open access, government mandates, new evaluation tools such as altmetrics, and the increased availability of information offered by search engines, discovery systems, and social networks. All elements of the information marketplace?libraries, publishers, and vendors?will continue to be impacted by the changing market conditions. The 6% average price increase of 2013 is expected to abide, hovering in the 6% to 7% range for 2014. Like the spring weather, market conditions could change before 2014 pricing is finalized, but the evidence available to date does not presage price relief for libraries.

Periodical Prices for High School and Public Libraries

Overall price increases for titles in EBSCO Publishing?s MasterFILE Premier are expected to be in the 5% to 6% range.

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Periodical Prices for University and College Libraries

Overall price increases for titles in EBSCO?s Academic Search Premier are expected to be in the 5% to 7% range for 2014.

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Measuring Impact

This year we were able to employ title and publisher data collected for this article to explore the relationship between prices and metrics used to assess journals like Impact Factor, Eigenfactor, and the Article Influence Score. The definitions follow:

  • The IMPACT FACTOR of a journal is the average number of citations received per paper published in that journal during the two preceding years. The impact factor of a journal is calculated by dividing the number of current-year citations to the source items published in that journal during the previous two years.
  • The EIGENFACTOR rates journals according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the score than citations from poorly ranked journals. Journals are considered to be influential if they are cited often by other influential journals.
  • The ARTICLE INFLUENCE SCORE is determined by the average influence of a journal?s articles over the first five years after publication. It is calculated by dividing a journal?s Eigenfactor Score by the number of articles in the journal, normalized as a fraction of all articles in all publications. The mean Article Influence Score is 1.00. A score greater than 1.00 indicates that each article in the journal has above-average influence. A score less than 1.00 indicates that each article in the journal has below-average influence.

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The approach taken to determine if there were relationships between journals prices and metrics was to look at data in price bands to see if more expensive journals had higher ranking than lower cost titles. The ISI pricing data for 2013 was divided into five price bands; journals prices less than $410, journals priced between $410 and $760, $760 and $1,455, $1,455 and $2,475, and titles priced at more than $2,475. These bands were selected to ensure that the number of titles in each area was reasonably comparable. The average for Impact Factor, Eigenfactor, and Article Influence Score for all titles in a price range was compared to the averages in the other price bands; the results are in table 6. The Impact Factor and the Eigenfactor tended to show a fairly strong increase with the increase in price. The Article Influence Source did not show a significant increase with the average for titles less than $410 price band showing an average of 0.98 and the most expensive titles showing an average of 1.2.

Although there were increases in the metrics for Impact Factor and Eigenfactor, the increases were not proportionate to the increase in price, since the average price ($5,172) for the most expensive journals was more than 20 times higher than the average price ($237) for the least expensive journals. The percent increase in prices for the lower cost titles was a bit higher than the more expensive titles, but that is also relative, considering that the 5.9% cost increase of the higher priced titles is itself more than the total average cost of the lower priced titles. Higher priced titles do have higher Impact Factors and Eigenfactors, but the increase in the metrics is small when compared to the increase in costs. Article Influence Score did not show a strong correlation between higher scores and prices. Ranking based on some form of citation analysis may not be strong indications of actual value. Many groups are exploring different sets of data that may be better descriptors of the impact of journals. The efforts to create altmetrics are still being developed, but better tools to help assess the impact of scholarly works would be welcomed by the community.


Stephen Bosch is Materials Budget, Procurement, and Licensing Librarian, University of Arizona Library, Tuscon. Kittie Henderson is Director, Academic and Law Divisions, EBSCO Information Services, Birmingham, AL

This article was featured in Library Journal's Academic Newswire enewsletter. Subscribe today to have more articles like this delivered to your inbox for free.

Source: http://lj.libraryjournal.com/2013/04/publishing/the-winds-of-change-periodicals-price-survey-2013/

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New imaging technology could reveal cellular secrets

Apr. 25, 2013 ? Researchers have married two biological imaging technologies, creating a new way to learn how good cells go bad.

"Let's say you have a large population of cells," said Corey Neu, an assistant professor in Purdue University's Weldon School of Biomedical Engineering. "Just one of them might metastasize or proliferate, forming a cancerous tumor. We need to understand what it is that gives rise to that one bad cell."

Such an advance makes it possible to simultaneously study the mechanical and biochemical behavior of cells, which could provide new insights into disease processes, said biomedical engineering postdoctoral fellow Charilaos "Harris" Mousoulis.

Being able to study a cell's internal workings in fine detail would likely yield insights into the physical and biochemical responses to its environment. The technology, which combines an atomic force microscope and nuclear magnetic resonance system, could help researchers study individual cancer cells, for example, to uncover mechanisms leading up to cancer metastasis for research and diagnostics.

The prototype's capabilities were demonstrated by taking nuclear magnetic resonance spectra of hydrogen atoms in water. Findings represent a proof of concept of the technology and are detailed in a research paper that appeared online April 11 in the journal Applied Physics Letters. The paper was co-authored by Mousoulis' research scientist Teimour Maleki, Babak Ziaie, a professor of electrical and computer engineering; and Neu.

"You could detect many different types of chemical elements, but in this case hydrogen is nice to detect because it's abundant," Neu said. "You could detect carbon, nitrogen and other elements to get more detailed information about specific biochemistry inside a cell."

An atomic force microscope (AFM) uses a tiny vibrating probe called a cantilever to yield information about materials and surfaces on the scale of nanometers, or billionths of a meter. Because the instrument enables scientists to "see" objects far smaller than possible using light microscopes, it could be ideal for studying molecules, cell membranes and other biological structures.

However, the AFM does not provide information about the biological and chemical properties of cells. So the researchers fabricated a metal microcoil on the AFM cantilever. An electrical current is passed though the coil, causing it to exchange electromagnetic radiation with protons in molecules within the cell and inducing another current in the coil, which is detected.

The Purdue researchers perform "mechanobiology" studies to learn how forces exerted on cells influence their behavior. In work focusing on osteoarthritis, their research includes the study of cartilage cells from the knee to learn how they interact with the complex matrix of structures and biochemistry between cells.

Future research might include studying cells in "microfluidic chambers" to test how they respond to specific drugs and environmental changes.

A U.S. patent application has been filed for the concept. The research has been funded by Purdue's Showalter Trust Fund and the National Institutes of Health.

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The above story is reprinted from materials provided by Purdue University. The original article was written by Emil Venere.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Charilaos Mousoulis, Teimour Maleki, Babak Ziaie, Corey P. Neu. Atomic force microscopy-coupled microcoils for cellular-scale nuclear magnetic resonance spectroscopy. Applied Physics Letters, 2013; 102 (14): 143702 DOI: 10.1063/1.4801318

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/ayYzbNTiLZE/130425160208.htm

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Survivors found trapped in collapsed Bangladesh factory

Forty survivors were found trapped in room in the garment factory that collapsed yesterday in Bangladesh.

By Al-Emrun Garjon and Julhas Alam,?Associated Press / April 25, 2013

On Thursday, rescuers searching for injured and missing found 40 survivors trapped in a room. On Wednesday, a huge section of an eight-story building splintered into a pile of concrete in Savar, near Dhaka, Bangladesh.

A.M.Ahad / AP

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"Save us, brother. I beg you, brother," Mohammad Altab moaned to the rescuers who could not help him. He had been trapped for more than 24 hours, pinned between slabs of concrete in the ruins of the garment factory building where he worked.

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"I want to live," he pleaded, his eyes glistening with tears as he spoke of his two young children. "It's so painful here."

Altab should not have been in the building when it collapsed Wednesday, killing at least 238 people.

No one should have.

After seeing deep cracks in the walls of the building on Tuesday, police had ordered it evacuated. But officials at the garment factories operating inside ignored the order and kept more than 2,000 people working, authorities said.

The disaster in Savar, an industrial suburb of Dhaka, the capital city, is the worst ever for Bangladesh's booming and powerful garment industry, surpassing a fire five months ago that killed 112 people and brought widespread pledges to improve the country's worker-safety standards.

Instead, very little has changed in Bangladesh, where wages, among the lowest in the world, have made it a magnet for numerous global brands. Companies operating in the collapsed building say their customers included retail giants such as Wal-Mart, Dress Barn and Britain's Primark.

On Thursday, hundreds of rescuers, some crawling through the maze of rubble in search of survivors and corpses, spent a second day working amid the cries of the trapped and the wails of workers' relatives gathered outside the Rana Plaza building, which housed numerous garment factories and a handful of other companies.

Rescuers on Thursday evening found 40 survivors trapped in a room on the fourth floor. Twelve were soon freed, and crews worked to get the others out safely, said Brig. Gen. Mohammed Siddiqul Alam Shikder, who is overseeing rescue operations. Crowds at the scene burst into applause as survivors were brought out, although no other details were immediately available.

An Associated Press cameraman who went into the rubble Thursday morning with rescue workers spoke briefly to Atlab, the man who pleaded to be saved. But the team was unable to free Atlab, who was trapped next to two corpses.

From deep inside the rubble, another survivor could be heard weeping as he called for help.

"We want to live, brother! It's hard to remain alive here. It would have been better to die than enduring such pain to live on. We want to live! Please save us," the man cried. It was not immediately clear if he or Atlab were among those later rescued.

After the cracks were reported, managers of a bank that had an office in the building evacuated their employees. The garment factories, though, kept working, ignoring the instructions of the local industrial police, said Mostafizur Rahman, a director of that police force.

Abdur Rahim, who worked on the fifth floor, said he and his co-workers had gone inside Wednesday morning despite seeing the cracks. He said a factory manager had assured people it was safe.

About an hour later, the building collapsed, and the next thing Rahim remembered was regaining consciousness outside.

Officials said they had made it very clear that the building needed to be evacuated.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/G3J1kk4rPqQ/Survivors-found-trapped-in-collapsed-Bangladesh-factory

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Boosting the powers of genomic science

Apr. 25, 2013 ? As scientists probe and parse the genetic bases of what makes a human a human (or one human different from another), and vigorously push for greater use of whole genome sequencing, they find themselves increasingly threatened by the unthinkable: Too much data to make full sense of.

In a pair of papers published in the April 25, 2013 issue of PLOS Genetics, two diverse teams of scientists, both headed by researchers at the University of California, San Diego School of Medicine, describe novel statistical models that more broadly and deeply identify associations between bits of sequenced DNA called single nucleotide polymorphisms or SNPs and say lead to a more complete and accurate understanding of the genetic underpinnings of many diseases and how best to treat them.

"It's increasingly evident that highly heritable diseases and traits are influenced by a large number of genetic variants in different parts of the genome, each with small effects," said Anders M. Dale, PhD, a professor in the departments of Radiology, Neurosciences and Psychiatry at the UC San Diego School of Medicine. "Unfortunately, it's also increasingly evident that existing statistical methods, like genome-wide association studies (GWAS) that look for associations between SNPs and diseases, are severely underpowered and can't adequately incorporate all of this new, exciting and exceedingly rich data."

Dale cited, for example, a recent study published in Nature Genetics in which researchers used traditional GWAS to raise the number of SNPs associated with primary sclerosing cholangitis from four to 16. The scientists then applied the new statistical methods to identify 33 additional SNPs, more than tripling the number of genome locations associated with the life-threatening liver disease.

Generally speaking, the new methods boost researchers' analytical powers by incorporating a priori or prior knowledge about the function of SNPs with their pleiotrophic relationships to multiple phenotypes. Pleiotrophy occurs when one gene influences multiple sets of observed traits or phenotypes.

Dale and colleagues believe the new methods could lead to a paradigm shift in CWAS analysis, with profound implications across a broad range of complex traits and disorders.

"There is ever-greater emphasis being placed on expensive whole genome sequencing efforts," he said, "but as the science advances, the challenges become larger. The needle in the haystack of traditional GWAS involves searching through about one million SNPs. This will increase 10- to 100-fold, to about 3 billion positions. We think these new methodologies allow us to more completely exploit our resources, to extract the most information possible, which we think has important implications for gene discovery, drug development and more accurately assessing a person's overall genetic risk of developing a certain disease."

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Story Source:

The above story is reprinted from materials provided by University of California, San Diego Health Sciences, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal References:

  1. Andrew J. Schork, Wesley K. Thompson, Phillip Pham, Ali Torkamani, J. Cooper Roddey, Patrick F. Sullivan, John R. Kelsoe, Michael C. O'Donovan, Helena Furberg, Nicholas J. Schork, Ole A. Andreassen, Anders M. Dale. All SNPs Are Not Created Equal: Genome-Wide Association Studies Reveal a Consistent Pattern of Enrichment among Functionally Annotated SNPs. PLoS Genetics, 2013; 9 (4): e1003449 DOI: 10.1371/journal.pgen.1003449
  2. Ole A. Andreassen, Wesley K. Thompson, Andrew J. Schork, Stephan Ripke, Morten Mattingsdal, John R. Kelsoe, Kenneth S. Kendler, Michael C. O'Donovan, Dan Rujescu, Thomas Werge, Pamela Sklar, J. Cooper Roddey, Chi-Hua Chen, Linda McEvoy, Rahul S. Desikan, Srdjan Djurovic, Anders M. Dale. Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate. PLoS Genetics, 2013; 9 (4): e1003455 DOI: 10.1371/journal.pgen.1003455

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/W-16k4bufPw/130425213754.htm

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Beyonce Proves She's Hotter Than Ever On 'Standing On The Sun' Preview

The same day Bey teased the new track in an H&M ad, she also performed 'Grown Woman' for the first time in Paris.
By Jocelyn Vena

Source: http://www.mtv.com/news/articles/1706309/beyonce-standing-on-the-sun-hm-preview.jhtml

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Eminem to Release New Album This Summer?

Source: http://www.thehollywoodgossip.com/2013/04/eminem-to-release-new-album-this-summer/

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Body size conveyed by voice determines vocal attractiveness

Apr. 24, 2013 ? Deep male voices and high-pitched female voices are perceived as more attractive because listeners gauge the speaker's body size from the frequency of their voice, according to research published April 24 in the open access journal PLOS ONE by Yi Xu from University College London (UK) and colleagues.

Studies of animals and birds reveal that listeners can perceive a caller's body size and intension based on the frequency, voice quality and formant spacing of a call. For example, low frequency growls are more likely to indicate larger body size, dominance or a potential attack, while higher frequency and pure-tone-like sounds suggest smaller size, submissiveness and fear.

The researchers tested whether a similar principle applied to human vocal attractiveness by asking male volunteers to listen to a female voice that was systematically altered for pitch, voice quality and formant spacing to signal a smaller body size. Female listeners heard a male voice that had been similarly altered to indicate a larger body size.

Results showed that male listeners preferred female voices with high pitch, breathy voice and wide formant spacing that correlated with a smaller body size, while females preferred to hear low-pitched male voices with low pitch and narrow formant spacing that suggested larger body size. But surprisingly, female listeners also preferred male voices that are breathy, which presumably softened the aggressiveness associated with a large body size. The authors conclude that despite the development of complex language, human vocal interactions still employ certain animal instincts.

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Story Source:

The above story is reprinted from materials provided by Public Library of Science.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Yi Xu, Albert Lee, Wing-Li Wu, Xuan Liu, Peter Birkholz. Human Vocal Attractiveness as Signaled by Body Size Projection. PLoS ONE, 2013; 8 (4): e62397 DOI: 10.1371/journal.pone.0062397

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/living_well/~3/PNeVo1djLZo/130424185157.htm

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Android App Video Review: Into the Dead

?

Into the Dead from PikPok is an endless first person runner game full of zombies, and ironically, in absolute defiance of all expectations and despite combining two of the most common tropes in mobile gaming, it's actually a very unique and stylish game unlike any other. That's probably due to the creativity of a developer like PikPok, though.

?

Essentially, you're just dropped in the middle of a zombie apocalypse world, and immediately have to start running. As you run, you'll notice one or two zombies in your path, and then one or two hundred. The idea is to keep pressing onward, slanting your run left or run via tilt or touch controls to dodge any zombies directly in your path. You don't have to dodge them perfectly. Even if you hit one to some extent while dodging, you'll glance off the side and stagger for a bit before regaining your composure. You'll also bounce off trees and other such obstacles in the same fashion. It's while you're staggered that things can get tricky in a jiffy. Also, you'll jump over fences and logs automatically.


Also on Android Apps

Instead of celebrating Earth Day once a year, adopt an eco-friendly consciousness. Zinio ?s digital newsstand saves 104 thousand trees per month, and here?s how you can get involved.


You aren't totally defenseless though. As you run, you'll see weapon crates marked by a glowing flare. As you complete mission objectives and reach higher levels of difficulty, you'll unlock cooler weapons, from shotguns and chainsaws to an eventual mini-gun. If you're having trouble picking up crates, they're also marked by a ring of birds in the sky, which you can see from a much greater distance. In the main mode, weapons serve to help you get through tricky choke points and corn fields, while in the massacre mode, they're the point of the game.

Everything is built around the coin and mission system. Coins earned through play and completed mission objectives can be used to buy starting perks, like extra ammo, a starting weapon, or a starting distance of 1,500 meters. They can also be used to get early access to weapons, and even to straight up bypass certain difficult mission objectives. Your gamer pride will probably keep you from doing this for a while, but believe me when I say that some objectives just aren't worth it, and will take too long to pull off. Naturally, you can buy coins in-app with real money. The game becomes repetitive and formulaic quickly, but what it lacks in variety, it excels with in style and presentation. No other runner has ever felt so atmospheric or tense, and the first time you run into a zombie that ends your run, it's kind of freaky. All in all, I can definitely recommend Into the Dead, as it's totally free.


The Best Educational Apps, Handpicked By Experts

Appolicious is pleased to introduce appoLearning.com, where parents, teachers and students find great education apps. Check out our introduction video here!


Source: http://www.androidapps.com/games/articles/13428-android-app-video-review-into-the-dead

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Apple docked $118,000 by Chinese court for violating authors' copyrights

Apple docked $118,000 by China court for violating authors' copyrights

Apple will have to pay three Chinese authors a total of $118,000 for stocking their books in its App Store without a proper say-so, according to China Daily. A court ruled that it was Apple's job to verify that third-party uploads met copyright requirements and that it had the means to do so since all the books in question were best-sellers. Apple's attorney declined to comment, but the court also suggested that similar online retailers should learn from the case "and improve their verification system" -- bringing perhaps another headache to would-be e-book stores in that nation.

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Via: ZDNet

Source: China Daily

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/N1DX_TdFUzA/

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Thursday, April 25, 2013

Watching Supervillains Try to Find Dates Through Speed Dating Is Hilarious

Supervillains are so consumed with being evil and doing bad things against humanity and/or superheroes that they don't really have time to go dating. Sad, right? What should they do? Why go speed dating! World of Heroes imagined how supervillains like Darth Vader, Joker, Bane, Cobra Commander, Doctor Octopus and others would do on a speed dating run. I think I'd let Cobra Commander or Bane holler. Doctor Octopus is too creepy. [World of Heroes via The Awesomer] More »
    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/Ssnx30C4jT8/watching-supervillains-try-to-find-dates-through-speed-dating-is-hilarious

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Monday, April 22, 2013

Andreessen, Schroepfer, Others Rally For More Women In CS At She++ Conference

noname-1Marc Andreessen and Mike Schroepfer delivered keynote addresses today at the she++ conference, sharing their thoughts on women in technology and growing the pool of talented engineers. ?If we?re building technology that the whole population uses, then we should have people of all backgrounds building that technology so that they build it for the audience that is themselves,? he told me.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/i3_NRupQS-8/

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Fed's Bernanke sees no U.S. inflation risks: Nowotny

By Karolos Grohmann BERLIN, April 19 (Reuters) - Though the Bundesliga has become a two-horse race between Borussia Dortmund and Bayern Munich in recent seasons, fears that it might suffer the fate of Spain are unfounded, Dortmund boss Hans-Joachim Watzke said on Friday. Champions League semi-finalists Dortmund, who take on Spain's Real Madrid on Wednesday in the first leg, won back-to-back Bundesliga titles in 2011 and 2012 before surrendering the trophy to fellow semi-finalists Bayern this season. ...

Source: http://news.yahoo.com/feds-bernanke-sees-no-u-inflation-risks-nowotny-210403995--business.html

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Random Numbers Help - C And C++ | Dream.In.Code


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    5 Replies - 50 Views - Last Post: 48 minutes ago Rate Topic: -----

    #1 makeitloud ?Icon User is online

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    Posted Today, 12:57 PM

    hello guys, i have a question. in this test program im making it does so if you get a problem wrong it re does the question, but it generates the same number, is their a way to generate a different number?
    
#include <iostream> #include <string> #include <ctime> using namespace std;  int main() { 	srand (time(NULL));  	int grade, operands[2], userAnswer;  	string quiz, name;  	char answer, again;  	cout << "What is your name?\n"; 	cin >> name; 	cout << "Were going to take a quiz, are you ready? <y/n>\n"; 	cin >> answer; 	if(answer == 'y' || answer == 'Y') 	{ 	cout << "Ok lets get started " << name << endl; 		cout << "First lets do a math problem.\n"; 		operands[0] = rand()%50; 		operands[1] = rand()%20; 		 		do 		{ 		cout << "What is " << operands[0] << " + " << operands[1] << " ?\n"; 		cin >> userAnswer; 		 	if(userAnswer==operands[0] + operands[1]) 	{ 		cout << "You got the Problem right, off to the next question\n"; 	} 	else 		{ 		cout << "Problem incorrect\n"; 		cout << "Would you like to try again?\n"; 		cin >> again; 		} 		}while(again == 'y' || again == 'Y'); 		 	} 	 	 	  	system("pause"); 	return 0; }


    Is This A Good Question/Topic? 0

    Replies To: random numbers help

    #2 CTphpnwb ?Icon User is offline

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    Re: random numbers help

    Posted Today, 01:12 PM

    Have you tried putting your "if" statement inside the do ... while loop instead of enclosing it?


    #3 makeitloud ?Icon User is online

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    Re: random numbers help

    Posted Today, 01:15 PM

    i dont understand what you are saying.


    #4 CTphpnwb ?Icon User is offline

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    Re: random numbers help

    Posted Today, 01:23 PM

    Think about it.


    #5 makeitloud ?Icon User is online

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    Re: random numbers help

    Posted Today, 05:32 PM

    
do 	{ 	if(answer == 'y' || answer == 'Y') 	{ 	cout << "Ok lets get started " << name << endl; 		cout << "First lets do a math problem.\n"; 		operands[0] = rand()%50; 		operands[1] = rand()%20; 		/*******************first question********************************/ 		 		 		cout << "What is " << operands[0] << " + " << operands[1] << " ?\n"; 		cin >> userAnswer; 		 	if(userAnswer==operands[0] + operands[1]) 	{ 		cout << "You got the Problem right, off to the next question\n"; 		system("cls"); 		 	} 	else 		{ 		cout << "Problem incorrect\n"; 		cout << "Would you like to try again?\n"; 		cin >> again; 		} 		}while(again == 'y' || again == 'Y');

    was this what you were talking about

    also on

    
char again;   

    im getting a run time error on it saying it is no initialized and i cant find the reason behind it. if you no anything about that. thank you

    #6 #define ?Icon User is online

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    Re: random numbers help

    Posted 48 minutes ago

    You could have a function for the math problem, and another to check whether to go again.


    Page 1 of 1


    Source: http://www.dreamincode.net/forums/topic/319084-random-numbers-help/

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